Ptk2 CLIA Kit for Mouse(Mus musculus) | EIAab.comPtk2 CLIA Kit for Mouse(Mus musculus)

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Ptk2 (Gene name),

Focal adhesion kinase 1 (Protein name ), FAK1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ptk2(Fadk;Fak;Fak1;Kiaa4203);

Protein name:

Focal adhesion kinase 1(FADK 1);

Alternative:

pp125FAK;Protein-tyrosine kinase 2(FRNK);pp125FAK;p125FAK;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with CAS family members. Interacts with GIT1. Component of a complex that contains at least FER, CTTN and PTK2/FAK. Interacts with BMX. Interacts with STEAP4. Interacts with ZFYVE21. Interacts with ESR1. Interacts with PIK3R1 or PIK3R2. Interacts with SRC. Interacts with EPHA2 (inactive form); participates to EPHA2 downstream signaling. Interacts with CD4; this interaction requires the presence of HIV-1 gp120. Interacts with EPHA1 (kinase activity-dependent) (By similarity). Interacts with SORBS1. Interacts with BCAR3. Interacts with RGNEF. Interacts with SHB. Interacts with PXN. Interacts with TGFB1I1.

Function:

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity). Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Subcellular Location:

Cell junction focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Constituent of focal adhesions.

Protein Attributes:

Sequence length:

1090

Sequence:

50:

100:

150:

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300:

350:

400:

450:

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600:

650:

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800:

850:

900:

950:

1000:

1050:

1090:

QQEYKKQMLT | AAHALAVDAK | NLLDVIDQAR | LKMLGQTRPH |

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

KEGG:

mmu:14083

String:

P34152

SMR:

P34152

UniGene:

Mm.254494

Pfam:

PF00373

Uniprot:

P34152

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ELISA Kit for Mouse FADK 1

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E1178c

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ELISA Kit for Mouse FADK 1

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E1178h

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ELISA Kit for Mouse FADK 1

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E1178r

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ELISA Kit for Mouse FADK 1

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E1178m

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96T

CLIA Kit for Mouse FADK 1

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U1178h

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CLIA Kit for Mouse FADK 1

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U1178c

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CLIA Kit for Mouse FADK 1

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U1178r

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CLIA Kit for Mouse FADK 1

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U1178m

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Polyclonal Antibody for Mouse FADK 1

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P1178Rb-m

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Polyclonal Antibody for Mouse FADK 1

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P1178Rb-r

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Polyclonal Antibody for Mouse FADK 1

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P1178Rb-h

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Monoclonal Antibody for Mouse FADK 1

Protein for Mouse FADK 1

R&D Technical Data

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Precision

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References

1.

"Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin."
Hanks S.K. , Calalb M.B. , Harper M.C. , Patel S.K.
Proc. Natl. Acad. Sci. U.S.A.89:8487-8491(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;PHOSPHORYLATION
strain: BALB/c.
tissue: Embryo.
2.

"Focal adhesion kinase."
Yamakawa N.
Submitted (1999-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 7)
strain: BALB/c.
tissue: Brain.
tissue: Embryo.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 8)
strain: C57BL/6J.
tissue: Placenta.
tissue: Thymus.
4.

"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R.F. , Ohara R. , Inamoto S. , Nagase T. , Ohara O. , Koga H.
Submitted (2005-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Fetal brain.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
strain: Czech II.
tissue: Mammary tumor.
6.

Bienvenut W.V. , Sandilands E. , Serrels B. , Brunton V.G. , Sumpton D.P. , Frame M.C.
Submitted (2008-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-19; 39-57; 77-86; 92-121; 132-177; 179-204; 210-218; 222-259; 313-319; 350-381; 465-492; 504-546; 589-616; 622-635; 666-703; 707-728; 735-762; 836-876; 885-971; 942-971; 980-993; 1001-1019 AND 1027-1082;PROTEIN SEQUENCE OF 386-451 (ISOFORM 3);CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;PHOSPHORYLATION AT SER-948;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Embryonic fibroblast.
7.

"Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity."
Burgaya F. , Toutant M. , Studler J.-M. , Costa A. , Le Bert M. , Gelman M. , Girault J.A.
J. Biol. Chem.272:28720-28725(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 391-460 (ISOFORMS 1 AND 2)
strain: ICR X Swiss Webster.
8.

Asano H. , Komiyama H.K. , Grant S.G.
Submitted (1996-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 391-417
strain: 129/SvJ.
9.

"Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase."
Schlaepfer D.D. , Hanks S.K. , Hunter T. , van der Geer P.
Nature372:786-791(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTEGRIN SIGNALING AND ACTIVATION OF MAP KINASES;INTERACTION WITH GRB2; BCAR1; SHC1 AND SRC;PHOSPHORYLATION AT TYR-963;MUTAGENESIS OF TYR-963
10.

"Interaction of focal adhesion kinase with cytoskeletal protein talin."
Chen H.C. , Appeddu P.A. , Parsons J.T. , Hildebrand J.D. , Schaller M.D. , Guan J.L.
J. Biol. Chem.270:16995-16999(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TLN1
11.

"Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases."
Calalb M.B. , Polte T.R. , Hanks S.K.
Mol. Cell. Biol.15:954-963(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-428; TYR-438; TYR-614 AND TYR-615;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;MUTAGENESIS OF TYR-428 AND 614-TYR-615;ENZYME REGULATION
12.

"Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK."
Furuta Y. , Ilic D. , Kanazawa S. , Takeda N. , Yamamoto T. , Aizawa S.
Oncogene11:1989-1995(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
13.

"Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase."
Chen H.C. , Appeddu P.A. , Isoda H. , Guan J.L.
J. Biol. Chem.271:26329-26334(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1;MUTAGENESIS OF TYR-428;PHOSPHORYLATION AT TYR-428
14.

"Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases."
Schlaepfer D.D. , Hunter T.
Mol. Cell. Biol.16:5623-5633(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-963;MUTAGENESIS OF TYR-963;INTERACTION WITH GRB2
15.

"Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src."
Schlaepfer D.D. , Hunter T.
J. Biol. Chem.272:13189-13195(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SHC1 AND ACTIVATION OF MAPK1/ERK2;PHOSPHORYLATION AT TYR-963;INTERACTION WITH GRB2
16.

"Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions."
Matsuya M. , Sasaki H. , Aoto H. , Mitaka T. , Nagura K. , Ohba T. , Ishino M. , Takahashi S. , Suzuki R. , Sasaki T.
J. Biol. Chem.273:1003-1014(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
17.

"A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions."
Ribon V. , Herrera R. , Kay B.K. , Saltiel A.R.
J. Biol. Chem.273:4073-4080(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SORBS1
18.

"Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase."
Fujita H. , Kamiguchi K. , Cho D. , Shibanuma M. , Morimoto C. , Tachibana K.
J. Biol. Chem.273:26516-26521(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
19.

"Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2."
Owen J.D. , Ruest P.J. , Fry D.W. , Hanks S.K.
Mol. Cell. Biol.19:4806-4818(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL SPREADING; MIGRATION AND PHOSPHORYLATION OF BCAR1;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;MUTAGENESIS OF TYR-428 AND 614-TYR-TYR-615;PHOSPHORYLATION AT TYR-428; TYR-614 AND TYR-615
20.

"p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor."
Gotoh T. , Cai D. , Tian X. , Feig L.A. , Lerner A.
J. Biol. Chem.275:30118-30123(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCAR3
21.

"FAK integrates growth-factor and integrin signals to promote cell migration."
Sieg D.J. , Hauck C.R. , Ilic D. , Klingbeil C.K. , Schaefer E. , Damsky C.H. , Schlaepfer D.D.
Nat. Cell Biol.2:249-256(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-428
22.

"Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion."
Xie B. , Zhao J. , Kitagawa M. , Durbin J. , Madri J.A. , Guan J.L. , Fu X.Y.
J. Biol. Chem.276:19512-19523(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT1;FUNCTION IN STAT1 PHOSPHORYLATION
23.

"The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase."
Izaguirre G. , Aguirre L. , Hu Y.P. , Lee H.Y. , Schlaepfer D.D. , Aneskievich B.J. , Haimovich B.
J. Biol. Chem.276:28676-28685(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ACTN1
24.

"Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies."
Nakamura K. , Yano H. , Schaefer E. , Sabe H.
Oncogene20:2626-2635(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-428; TYR-438; TYR-614; TYR-615; TYR-899 AND TYR-963
25.

"Regulation of focal adhesion kinase by a novel protein inhibitor FIP200."
Abbi S. , Ueda H. , Zheng C. , Cooper L.A. , Zhao J. , Christopher R. , Guan J.L.
Mol. Biol. Cell13:3178-3191(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RB1CC1
26.

"Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration."
Xie Z. , Sanada K. , Samuels B.A. , Shih H. , Tsai L.H.
Cell114:469-482(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-770
27.

"The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells."
Holmqvist K. , Cross M.J. , Riley D. , Welsh M.
Cell. Signal.15:171-179(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
28.

"Direct interaction of focal adhesion kinase with p190RhoGEF."
Zhai J. , Lin H. , Nie Z. , Wu J. , Canete-Soler R. , Schlaepfer W.W. , Schlaepfer D.D.
J. Biol. Chem.278:24865-24873(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ARHGEF28;MUTAGENESIS OF LEU-1072
29.

"PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation."
Kadare G. , Toutant M. , Formstecher E. , Corvol J.C. , Carnaud M. , Boutterin M.C. , Girault J.A.
J. Biol. Chem.278:47434-47440(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIAS1
30.

"Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast."
Gupta A. , Lee B.S. , Khadeer M.A. , Tang Z. , Chellaiah M. , Abu-Amer Y. , Goldknopf J. , Hruska K.A.
J. Bone Miner. Res.18:669-685(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LPXN
31.

"Focal adhesion kinase regulation of N-WASP subcellular localization and function."
Wu X. , Suetsugu S. , Cooper L.A. , Takenawa T. , Guan J.L.
J. Biol. Chem.279:9565-9576(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WASL;PHOSPHORYLATION OF WASL
32.

"Focal adhesion kinase in netrin-1 signaling."
Ren X.R. , Ming G.L. , Xie Y. , Hong Y. , Sun D.M. , Zhao Z.Q. , Feng Z. , Wang Q. , Shim S. , Chen Z.F. , Song H.J. , Mei L. , Xiong W.C.
Nat. Neurosci.7:1204-1212(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCC
33.

"Activation of FAK and Src are receptor-proximal events required for netrin signaling."
Li W. , Lee J. , Vikis H.G. , Lee S.H. , Liu G. , Aurandt J. , Shen T.L. , Fearon E.R. , Guan J.L. , Han M. , Rao Y. , Hong K. , Guan K.L.
Nat. Neurosci.7:1213-1221(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCC
34.

"Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis."
Shen T.L. , Park A.Y. , Alcaraz A. , Peng X. , Jang I. , Koni P. , Flavell R.A. , Gu H. , Guan J.L.
J. Cell Biol.169:941-952(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
35.

"Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness."
Brown M.C. , Cary L.A. , Jamieson J.S. , Cooper J.A. , Turner C.E.
Mol. Biol. Cell16:4316-4328(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
36.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-397 (ISOFORMS 3; 4 AND 6);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
37.

"Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation."
Braren R. , Hu H. , Kim Y.H. , Beggs H.E. , Reichardt L.F. , Wang R.
J. Cell Biol.172:151-162(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
38.

"FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX."
Chang F. , Lemmon C.A. , Park D. , Romer L.H.
Mol. Biol. Cell18:253-264(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL SPREADING; PHOSPHORYLATION OF ARHGEF7; RAC1 TARGETING TO FOCAL ADHESIONS AND RAC1 ACTIVATION;INTERACTION WITH ARHGEF7
39.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-614 AND TYR-615;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
40.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-614; TYR-615 AND TYR-963;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
41.

"Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation."
Lim S.T. , Chen X.L. , Lim Y. , Hanson D.A. , Vo T.T. , Howerton K. , Larocque N. , Fisher S.J. , Schlaepfer D.D. , Ilic D.
Mol. Cell29:9-22(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN REGULATION OF P53/TP53 LEVELS; CELL PROLIFERATION AND CELL SURVIVAL;INTERACTION WITH MDM2;SUBCELLULAR LOCATION
42.

"Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth."
DiMichele L.A. , Hakim Z.S. , Sayers R.L. , Rojas M. , Schwartz R.J. , Mack C.P. , Taylor J.M.
Circ. Res.104:1201-1208(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE (ISOFORM 9)
43.

"Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis."
Chu P.Y. , Huang L.Y. , Hsu C.H. , Liang C.C. , Guan J.L. , Hung T.H. , Shen T.L.
J. Biol. Chem.284:20215-20226(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF GRB7;INTERACTION WITH GRB7
44.

"Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling."
Pylayeva Y. , Gillen K.M. , Gerald W. , Beggs H.E. , Reichardt L.F. , Giancotti F.G.
J. Clin. Invest.119:252-266(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SRC-MEDIATED PHOSPHORYLATION OF BCAR1;ROLE IN DISEASE
45.

"Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways."
Clemente C.F. , Xavier-Neto J. , Dalla Costa A.P. , Consonni S.R. , Antunes J.E. , Rocco S.A. , Pereira M.B. , Judice C.C. , Strauss B. , Joazeiro P.P. , Matos-Souza J.R. , Franchini K.G.
J. Mol. Cell. Cardiol.52:493-501(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
46.

"The role of focal adhesion kinase in early development."
Chatzizacharias N.A. , Kouraklis G.P. , Theocharis S.E.
Histol. Histopathol.25:1039-1055(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN DEVELOPMENT
47.

"Focal adhesion kinase: exploring Fak structure to gain insight into function."
Hall J.E. , Fu W. , Schaller M.D.
Int. Rev. Cell Mol. Biol.288:185-225(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; SUBUNIT; PHOSPHORYLATION AND ENZYME REGULATION
48.

"The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin."
Hayashi I. , Vuori K. , Liddington R.C.
Nat. Struct. Biol.9:101-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 959-1084;INTERACTION WITH PXN

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